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Filtered Search Results
Medchemexpress LLC Firmonertinib mesylate | 2130958-55-1 | 100.0% | 664.70 | 1 G
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Firmonertinib mesylate is an orally active, mutant-selective, and blood-brain barrier penetrant EGFR inhibitor. It effectively inhibits EGFR active mutations and the T790M acquired resistant mutation, making it a valuable compound for cancer research, particularly for advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation.
- Orally active
- Mutant-selective
- Blood-brain barrier penetrant EGFR inhibitor
- Inhibits EGFR active mutations
- Inhibits T790M acquired resistant mutation
- Potential for cancer diseases research
- Especially for advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation
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Ambeed AMBEED
5000869775 DBCO-AMINE 250MG
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Medchemexpress LLC 8-Bromoisoquinoline | 63927-22-0 | 99.51% | C9H6BrN | 5 G
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8-Bromoisoquinoline is a biochemical reagent that can be used as a biological material or organic compound for life science-related research. It is for research use only.
- Purity: 99.51%
- Molecular weight: 208.05
- Formula: C9H6BrN
- CAS No.: 63927-22-0
- Appearance: Solid, off-white to yellow color
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TARGETMOL CHEMICALS INC Propidium Iodide 100MG
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Also available in 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Propidium Iodide (PI) is a red fluorescent dye utilized for cell staining and is suitable for fluorescence microscopy, confocal microscopy, flow cytometry, and fluorometer analysis. In aqueous solution, the Ex/Em of PI is 493/636 nm. Upon binding with nucleic acid, the Ex/Em shifts to 535/617 nm, enhancing the fluorescence signal 20-30 times. Purity 98%
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![Medchemexpress LLC Sulfur, [3-cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]... | 1448316-08-2 | 99.9% | 558.53 g·mol⁻¹ | C26H19F5N6OS | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000212005.png-250.jpg)
Medchemexpress LLC Sulfur, [3-cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]... | 1448316-08-2 | 99.9% | 558.53 g·mol⁻¹ | C26H19F5N6OS | 1 ML
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BAY-826 is a selective, potent small-molecule inhibitor of the TIE-2 kinase supplied for research use. It binds TIE-2 with high affinity (Kd ≈ 1.6 nM) and is provided as a 10 mM solution in DMSO (1 mL) or as solid quantities. Typical applications include biochemical kinase assays and cell-based studies of angiogenesis signaling pathways.
- Selective TIE-2 inhibition with Kd ≈ 1.6 nM.
- Available as 10 mM solution in DMSO (1 mL) and multiple solid sizes.
- High purity suitable for research applications.
- Molecular formula C26H19F5N6OS; molecular weight 558.53 g·mol⁻1.
- Soluble in DMSO for convenient assay preparation.
- Suitable for biochemical and cell-based assays targeting TIE-2 signaling.
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eMolecules 1309357-15-0 | Medchem Express | Silmitasertib (sodium salt) | 5mg | 446271127 | HY-50855B | MFCD28385881 | 371.76 | C19H11ClN3NaO2
Ambeed | 4-Fluoro-5-iodo-2-methylbenzoic acid | 100mg | 714088591 | A759995 | 1533441-18-7 | MFCD26863042 | 280.037 | C8H6FIO2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
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Ambeed AMBEED
5000885210 ISOQUINOLIN-4-AMINE 10G
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TARGETMOL CHEMICALS INC SB 202190 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38alpha and p38beta2 (IC50=50/100 nM) selectively and cell-permeably. SB 202190 has antitumor activity and also induces the differentiation of human embryonic stem cells into cardiomyocytes. Purity 99.67%
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Medchemexpress LLC Paliperidone (9-Hydroxyrisperidone) | 144598-75-4 | 99.4% | C23H27FN4O3 | 200 MG
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Paliperidone (9-Hydroxyrisperidone) is the major active metabolite of Risperidone, functioning as a dopamine D2 and 5-HT2A antagonist. It also exhibits antagonist activity at α1 and α2 adrenergic receptors and H1-histaminergic receptors, demonstrating efficacy as an antipsychotic agent against schizophrenia.
- Major active metabolite of risperidone
- Dopamine D2 antagonist
- 5-HT2A antagonist
- Antagonist at α1 and α2 adrenergic receptors
- Antagonist at H1-histaminergic receptors
- Effective antipsychotic agent against schizophrenia
- For research use only
- Increases caspase-3 activity in neuroblastoma cells
- May modulate Akt1/GSK3β pathway to protect SK-N-SH cells from glutamate damage
- Can protect SK-N-SH cells from apoptosis induced by glutamate
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Ambeed AMBEED
5000868362 2-METHYLQUINOLIN-6-AMINE 1GR
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Medchemexpress LLC U0126-EtOH | 1173097-76-1 | 98.9% | 200MG
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U0126-EtOH | 1173097-76-1 | 98.9% | 200MG
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Apexbio Technology LLC Indoximod (NLG-8189) 110117-83-4 200mg
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Indoximod (NLG-8189 CAS 110117-83-4) is an orally bioavailable small molecule that targets the indoleamine 2 3-dioxygenase (IDO) pathway a key regulator of tryptophan metabolism involved in tumor-mediated immune suppression By blocking IDO activity indoximod reduces the expansion of regulatory T cells (Tregs Foxp3 /CD4 /CD25 ) thereby attenuating tumor-associated immune tolerance Preclinical studies have demonstrated that indoximod enhances adaptive immune responses to antigens and dendritic cell vaccines and its combination with chemotherapeutics such as docetaxel has shown increased toxicity without reaching a maximum tolerated dose at 2000 mg twice daily Indoximod serves as a valuable tool in investigating immunoregulatory mechanisms and immunotherapy strategies in cancer research
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Medchemexpress LLC Dd-03-171 | 2366132-45-6 | 98.7% | 25MG
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Dd-03-171 | 2366132-45-6 | 98.7% | 25MG
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Apexbio Technology LLC U0126 200mg
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U0126 (CAS 109511-58-2) is a selective non-ATP competitive inhibitor of the MAPK/ERK kinase (MEK1/2) pathway interfering with downstream ERK1/2 activation By inhibiting MEK1/2 activity U0126 modulates cellular processes including proliferation differentiation and survival Additionally U0126 has been reported to suppress autophagy and mitophagy pathways This compound is widely used in biomedical research to investigate MAPK signaling dynamics as well as to explore the regulation of autophagic and mitochondrial quality control mechanisms in various cell models
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Medchemexpress LLC 7-Azaindazole | 271-73-8 | 119.12 | 10 G
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7-Azaindazole is a biochemical reagent that serves as a versatile building block in chemical synthesis. It can be used as a biological material or organic compound for life science related research.
- Used as a ligand for ruthenium (Ru) complexes as a potential anticancer agent.
- Used for the synthesis of various derivatives for numerous applications, such as anticancer and antiviral studies.
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